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. 2022 Sep 6;12(9):1390. doi: 10.3390/life12091390

Table 5.

Summary of findings of animal studies on fluid administration and IAH.

Author Year Population Intervention Results
Schachtrupp et al. [119] 2005 12 Pigs:
  • -

    6 intervention group (IAP to 30 mmHg)

  • -

    6 control group

 Fluid intake:
Intervention group vs. control (p < 0.01)
10570 ± 1928 mL vs.
3918 ± 1042 mL		 Acidosis, liver, bowel, kidney and lung damage higher in intervention group (p < 0.01)
Moore-Olufemi et al. [117] 2005 44 Rats
Experiment 1: 20 mL/kg saline
Experiment 2: 80 mL/kg saline
In each experiment 4 groups
  • -

    no venous HTN/no resuscitation (sham, n = 6),

  • -

    venous HTN/resuscitation (n = 6),

  • -

    no venous HTN/resuscitation (n = 6),

  • -

    venous HTN/no resuscitation (n = 4)

 A mesenteric venous hypertension/gut edema model was created to evaluate whether gut edema caused by acute mesenteric venous hypertension and/or crystalloid resuscitation is associated with impaired intestinal transit, mucosal barrier dysfunction, and/or injury Delayed intestinal transit, increased permeability, and decreased epithelial resistance are associated with gut edema
Chang et al. [118] 2016 48 rats:
  • -

    Sham group (n = 8)

  • -

    shock group (n = 8)

  • -

    LR group (n = 8)

  • -

    melatonin group and LR (n = 8)

  • -

    HS + LR group (n = 8)

  • -

    HES + LR group (n = 8)

 Induced portal hypertension, hemorrhage to a MAP of 40 mmHg for 2 h (except for sham group)
Collected blood reinfused and treatment with:
  • -

    LR (30 mL/h),

  • -

    melatonin (50 mg/kg) + LR,

  • -

    HS (6 mL/kg) + LR,

  • -

    HES 30 mL/kg +LR.

  • -

    shock: no fluids

 Melatonin use associated with less inflammatory and oxidative injury, less intestinal permeability and injury, lower incidence of secondary IAH

LR: Ringer’s lactate solution, HES: hydroxyethyl starch, IAH: intra-abdominal hypertension.