Table 2.
Case reports with ICI-associated pericarditis.
| Study | Patient Characteristics | CV Side Effect | Symptoms | Diagnosis | Pre-Existent CVD | ICI | Type of Cancer | Pericarditis Onset | Concomitant Treatments | Pericarditis Treatment | Evolution | Concomitant AID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Khan, 2019 |
♂, 62 | pericarditis | dyspnea | CT, echocardiogram, ECG, TnI, BNP | not mentioned | PD-1i | tonsillar cancer (squamous) | 15 weeks | not mentioned | pericardiocentesis, prednisone | resolution | not mentioned |
| Arora, 2020 |
♂, 83 | pericarditis | marked fatigue weakness chest pain orthopnea left eye ptosis |
TnI, CK, TTE, brain MRI | Hypertension, HyperlipidemiaAtrial fibrillation |
PD-1i | melanoma | 1 month after first dose | not mentioned | colchicine and naproxen IV methylprednisolonePlasmapheresis Intubation |
inability to reduce ventilatory support–transitioned to comfort measures |
Hepatitis MG |
| de Almeida, 2018 | ♂, 69 | pericarditis | dyspnea, tachycardia, low-grade fever |
CT, echocardiogram | not mentioned | PD-1i | NSCLC (adenocarcinoma) | 48 weeks | not mentioned | pericardiocentesis, prednisone | favorable | thyroiditis |
| Oristrell, 2018 | ♀, 55 | pericarditis | pericardial chest pain | echocardiogram, ECG, TnI | not mentioned | PD-1i | ductal carcinoma of the left breast | 30 weeks | not mentioned | Pericardiocentesis followed by pericardiectomy steroids | favorable | not mentioned |
| Zarogoulidis, 2017 | ♂, 60 | pericarditis | not mentioned | not mentioned | not mentioned | PD-1i | NSCLC | 17 weeks | not mentioned | pericardiocentesis mPSL | favorable | not mentioned |
| Öztürk, 2021 |
♂, 61 | pericarditis | not mentioned | CT, echocardiogram, MRI | not mentioned | PD-1i | NSCLC | 17 weeks | pemetrexed | not mentioned | not mentioned | not mentioned |
| Moriyama, 2021 |
♂, 58 | pericarditis | fatigue, limb oedema, increased body weight | echocardiogram, cardiac CT, cardiac catheterization, EMB, MRI, ECG, TnT | not mentioned | PD-1i | NSCLC | 77 weeks | not mentioned | prednisolone, furosemide, mPSL, infliximab | favorable | autoimmune hepatitis |
| Jacobs, 2021 | ♂, 54 | pericarditis | chest pain, general malaise, dyspnea | echocardiogram, CT, MRI, ECG, TnI | not mentioned | PD-1i | NSCLC (adenocarcinoma) | 5 weeks | carboplatin + pemetrexed + | mPSL | fatal | not mentioned |
| Dasanu, 2016 | ♀, 65 | pericarditis | progressive dyspnea, chest discomfort | X-ray, CT, echocardiogram, ECG | not mentioned | PD-1i | melanoma (nodular type) | 37 weeks | not mentioned | pericardiocentesis, mPSL | favorable | abnormal thyroid function, hepatitis, rash |
| Dhenin, 2019 | ♀, 79 | pericarditis | intense thoracic pain, increasingwhen leaning, fatigue, general malaise | echocardiogram, ECG | hypertension | PD-1i | NSCLC (adenocarcinoma) | 3 weeks | not mentioned | mPSL | favorable | rash, colitis, MG |
Abbreviations: CT, computer tomography; ECG, electrocardiography; EMB, endomyocardial biopsy; IV, intravenous; LAFB, left anterior fascicular block; mPSL, methylprednisolone; MG, myasthenia gravis; MRI, magnetic resonance imaging; NSCLC, non-small cell lung cancer; PD-1i, programmed cell death 1 inhibitor; Tn, troponin.