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. 2022 Sep 13;23(18):10587. doi: 10.3390/ijms231810587

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Simplified scheme of the metabolic pathways analyzed in papillary (PRCC) and clear cell renal cell carcinoma (CCRCC). Red and blue arrows on left and right side of black ones indicate the characteristic rewiring of metabolic pathways in PRCCs and in CCRCCs, respectively. High expressions of certain enzymes suggest balanced nutrient utilization, intensive glutaminolysis (GLS), acetate utilization (ACSS2), fatty acid oxidation (CPT1A), and oxidative phosphorylation (ATPB) were detected in PRCCs (thick red arrows), while high expressions of glycolytic enzymes (GLUT1, HXK2, PFKP) could correlate with higher glycolytic capacity in CCRCCs (thick blue arrows). Created with BioRender.com.