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Hypothesis: Accelerating reversal of elevated ligand-free MOR-μ* activity to the resting MOR-μ state, 6BN gradually reverses the opioid-dependent state, directly binding to MOR-μ* without competing with opioid agonists that have low affinity to MOR-μ*. The following term is suggested for this action of 6BN: ‘retrograde addiction modulation’.
