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Schematic overview of the proposed mechanism of CNP protection against glutamate-induced neuronal death in HT22 hippocampal neuronal cells. CNP can directly scavenge and suppress the intracellular ROS and also activate the cellular antioxidant enzyme genes via SIRT1/Nrf2 survival pathway, resulting in the inhibition of neurotoxicity and apoptotic neuronal death caused by glutamate in HT22 cells.
