Table 4.
Gelatinase polymorphisms in diseases accompanying type 2 diabetes.
| Disease | Gelatinase | SNP | Association | |
|---|---|---|---|---|
| Retinopathy | ||||
| MMP-2 | −790 T/G (rs243864) | increased risk of the disease | S. Sarray et al. (2022) [56] | |
| −1575 G/A (rs243866) | increased risk of the disease | S. Sarray et al. (2022) [56] | ||
| −1306 C/T (rs243865) | doubled risk of the disease | J. Yang et al. (2010) [34] | ||
| marginally significant increased risk of disease in males | M. Beránek et al. (2008) [57] | |||
| MMP-9 | −1562 C/T (rs3918242) | possible risk factor for the disease | K. Singh et al. (2017) [55] | |
| Nephropathy | ||||
| MMP-2 | −1306 C/T (rs243865) | the presence of the C allele was associated with disease susceptibility and progression | S.R. Gantala et al. (2018) [60] | |
| MMP-9 | +279 A/G (rs17576) | the presence of the GG genotype was independently associated with disease | C. Albert et al. (2019) [58] | |
| −1562 C/T (rs3918242) | the T allele was a protective factor, while the C allele contributed to the disease | S. Feng et al. (2016) [59] | ||
| the T allele reduces the risk of disease | Z. Zhang et al. (2015) [61] | |||
| Diabetic foot ulcers | ||||
| MMP-9 | −1562 C/T (rs3918242) | presence of allele T leads to a higher risk of developing the disease | K. Singh et al. (2013) [39] | |
| Macroangiopathy | ||||
| MMP-9 | −1562 C/T (rs3918242) | the presence of the T allele was higher in patients with disease | Y. Wang et al. (2010) [62] | |
| Cardiovascular comorbidity | ||||
| MMP-2 | −1306 C/T (rs243865) | possession of the T allele was associated with a reduced risk of disease | M. Buraczynska et al. (2015) [63] | |