Figure 1.

Schematic representation of the study design. Three out of eighteen goats were necropsied on the day of arrival and served as non-inoculated controls. Nasal and rectal swabs, blood, and tissue samples were collected. After acclimatisation, the remaining fifteen goats were intranasally inoculated with the SARS-CoV-2 B.1.351/Beta variant (2 mL of 1 × 10⁶ TCID₅₀/animal). At 2, 4, 7,10, and 18 days post-infection, three goats were necropsied each day and nasal and rectal swabs, blood, and tissues were collected. Clinical signs and rectal temperature were recorded daily.