Figure 5.

Number of active compounds related to Alzheimer’s disease and the respective number of targets they can modulate simultaneously (Data retrieved in August 2022 from ChEMBL database v31). To process the data, first targets related to AD were extracted from the Open Target Platform, then data was enriched with Uniprot IDs via Uniprot API and a local mirror of ChEMBL database v31. For those proteins with bioactive reports or reported as part of drug mechanisms on ChEMBL, we retrieved the targets and drugs names, compounds ChEMBL IDs, pchembl_value related to the activity, and the drug or compound phases of developments as itself and for the indication (Alzheimer in this case). Uniprot API queries, local ChEMBL queries, and data handling were performed with KNIME 4.6.1 platform. Detailed information can be found at https://osf.io/by86r/.