Table 3.
Water Solubility | Caco-2 Permeability | Intestinal Absorption | Skin Permeability | P-gp Substrate | P-gp I Inhibitor | P-gp II Inhibitor | |
---|---|---|---|---|---|---|---|
Units | Log mol/L | Log Papp in 10−6 cm/s | % | cm/s | Categorical (Yes/No) | ||
Gallic acid | −1.64 | −0.08 | 43.37 | −2.73 | No | No | No |
Syringic acid | −1.84 | 0.49 | 73.07 | −2.73 | No | No | No |
Trans-ferulic acid | −2.11 | 0.17 | 93.68 | −2.72 | No | No | No |
Myricetin | −3.01 | 0.09 | 65.93 | −2.73 | No | No | No |
Catechin gallate | −3.70 | −1.26 | 62.09 | −2.73 | No | No | Yes |
Caffeic acid | −1.89 | 0.63 | 69.40 | −2.72 | No | No | No |
Chlorogenic acid | −1.62 | −0.84 | 36.37 | −2.73 | No | No | No |
Arbutin | −0.71 | 0.00 | 38.02 | −2.80 | No | No | No |
Trimethoxyflavone | −4.11 | 1.40 | 98.07 | −2.57 | No | Yes | Yes |