Table 3.
Summary of disulfide-containing redox-responsive liposomes.
| Liposome Components | Disulfide Source | Payload | Biological Evaluation | Ref. |
|---|---|---|---|---|
| SS-PC, cholesterol, DSPE-PEG2000 | 3-(tritylthio)propionic acid in SS-PC | PTX | MCF-7, A549 (in vitro), 4T1 tumor-bearing BALB/c mice (in vivo) | [91] |
| SS-PC, DSPC, DSPE-PEG2000, Cholesterol | 3-(tritylthio)propionic acid in SS-PC | Irinotecan | MCF-7, A549 (in vitro) 4T1 tumor-bearing BALB/c mice and SD rats (in vivo) |
[92] |
| CPT-SS-GPC | 3-(tritylthio)propionic acid of different chain lengths (3 and 11) & 2-(pyridyl-disulfanyl)ethanol | CPT | MCF-7, HepG2, A549 (in vitro) MCF-7 inoculated BALB/c mice (in vivo) |
[93] |
| Chol-SPG, Glucose, Chol-TPP | DPA | DOX & LND | C6 and bEnd.3 (in vitro) C6-bearing Kunming mice (in vivo) |
[7] |
| PTX-SS-lysophosphatidylcholine, cholesterol, EPC, mPEG2000-DSPE | 2-hydroxyethyl disulfide | PTX | MCF-7, A549 (in vitro) | [94] |
| DSPE-PEG2000-Estrogen, Chol-SS-COOH, COS | DPA | DOX | MG63, L02 (in vitro) MG63 osteosarcoma inoculated BALB/c mice (in vivo) |
[95] |
| Chol-SS-mPEG, Hyaluronic acid | DPA | DOX | L02, MG63 (in vitro) SD rats and MG63 inoculated BALB/c mice (in vivo) |
[96] |
| MPA-SS-NH2, PPa, Lyso-PC, EDC, DMAP | AEDP | NLG8189 | 4T1 (in vitro) 4T1 breast cancer inoculated BALB/c mice |
[97] |