Table 4.
Summary of disulfide-containing redox-responsive nanogels.
| Nanogel Components | S-S Source and Position | S-S Cross-Linking Synthetic Route | Payload | Biological Evaluation | Ref. |
|---|---|---|---|---|---|
| EDDET, PETMA, TEA, Pluronic-127 | EDDET and PETMA (crosslinker) | Radical polymerization | Rhodamine B dye | HeLa (in vitro) | [98] |
| 2-(2-methoxyethoxy) ethyl methacrylate, oligo(ethylene glycol) methacrylate, BAC | BAC (crosslinker) |
Radical polymerization | DOX | HEK-293T, HeLa (in vitro) | [99] |
| 1′-(2-methacryloxyethyl)-3′,3′-dimethyl-6-nitro-spiro(2H-1-benzo-pyran-2,2′-indoline), acrylic acid, BAC | BAC (crosslinker) |
Radical polymerization | DOX | MCF-7 (in vitro) | [100] |
| N-Isopropylacrylamide (NIPA), N-hydroxyethylacrylamide (HEAA), BAC | BAC (crosslinker) | Radical polymerization | Rhodamine 6G Dye, propranolol | L929 (in vitro) | [101] |
| PVOH-b-PNVCL | DPA (crosslinker) | Radical polymerization | Nile red | MEL-5, L929 (in vitro) | [122] |
| MAHA, CBA | CBA (crosslinker) | Radical polymerization | DOX | H22, LNCaP (in vitro), BALB/c mice injected with LNCaP, ICR mice injected with H22 (in vivo) | [120] |
| BLG-NCA, LC-NCA, mPEG1900-NH2 | L-cystine (crosslinker) | ROP | indomethacin | HeLa (in vitro) | [103] |
| mPEG-P(LP-co-LC) | L-cystine (crosslinker) | ROP | DOX | RM-1 (in vitro), C57BL/6 mice injected with RM-1 cells (in vivo) | [119] |
| R9-PEG-P(LP-co-LC) | L-cystine (crosslinker) | ROP | HCPT | BC 5637 (in vitro), SD rats with orthotopic BC, C57BI/6 mice with orthotopic BC (in vivo) | [118] |
| DMA-PLL-LC | L-cystine (crosslinker) | ROP | DOX | HepG2 (in vitro) | [117] |
| AMPD, BAC, PEG | BAC (crosslinker) | Michael addition polymerization | FITC-dextran | - | [104] |
| Pe-PCL-b-PAA | 2-hydroxyethyl disulfide (crosslinker) | Branched arm crosslinking | DOX | C6 glioma cells, fibroblast cells, HaCat cells (in vitro) | [105] |
| poly(N-vinylpyrrolidone-co-N-vinylformamide), DMAP, dithioglycolic acid | DMAP + dithiodiglycolic acid (crosslinker) | Self-crosslinking | DOX | HeLa (in vitro) | [64] |
| PSM, furfuryl amine, hydrazine, DTME | DTME (crosslinker) | Self-crosslinking | DOX | HepG2, HEK293 (in vitro) | [106] |
| 2,6-diamino pyridine, uracil-functionalized poly(p-phenylenevinylene) | DTSP (crosslinker) | Self-crosslinking | DOX | HeLa (in vitro) | [107] |
| Hyaluronic acid, cystamine, gold nanorods (AuNRs) | Cystamine (crosslinker) | Self-crosslinking | DOX | MCF-7, drug-resistant MCF-7 ADR (in vitro) | [108] |
| Alginate, cystamine | Cystamine (crosslinker) | Self-crosslinking | DOX | CAL-72 (in vitro) | [121] |
| Xanthan, cystamine tetra-hydrazine, | Cystamine tetra-hydrazine (crosslinker) | Self-crosslinking | DOX | HeLa, 3T3 cells (in vitro) | [102] |
| MAA, CPT, Bis, HSEMA | HSEMA (linker) | - | CPT | HepG2 (in vitro) HepG2 tumor-bearing BALB/c mice (in vivo) |
[109] |