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. 2022 Sep 9;10(9):1508. doi: 10.3390/vaccines10091508

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Changes in mean arterial pressure (MAP) and heart rate (HR) elicited by 3 consecutive doses of MA (2 mg/kg, i.v.) in male (n = 10) and female (n = 11) Sprague-Dawley rats, prior to and after passive immunization with anti-MA antibodies. (A,B) changes in MAP elicited by MA in male and female rats, respectively. Pressor responses were significantly (* = p < 0.05) reduced between the first and third MA dosings in male and female rats. After immunization, the pressor responses to MA were significantly (# = p < 0.05) smaller than during control (treatment effect). (C,D) changes in HR elicited by MA in male and female rats, respectively. There was a significant effect of dose on HR, but no significant differences in the HR responses before and after immunization (treatment effect). There was no significant interaction between dose and treatment.