Table 4.
LC-HRMS Chiral separation results of the three 4-methylaminorex derivatives. Retention times (t) of both enantiomers, separation factors (α) and chromatographic resolution (Rs) are given. Conditions: Column: Lux i-Amylose-1, 250 × 4.6 mm (5 µm), mobile phase: n-hexane: isopropanol: diethylamine (90:10:0.1), column temperature 25 ± 1 °C, flow rate: 2.0 mL/min, detection wavelength: 220 nm, injection volume: 5 µL.
| Compound | t1 | t2 | α | Rs |
|---|---|---|---|---|
| 4F-MAR | 6.36 | 8.99 | 1.53 | 9.49 |
| 4C-MAR | 7.41 | 13.01 | 1.93 | 14.70 |
| 4B-MAR | 8.21 | 15.54 | 2.08 | 16.41 |