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. 2022 Sep 9;13:937108. doi: 10.3389/fimmu.2022.937108

Table 1.

Main blood tests of the patient at the time of the two episodes of hemophagocytic lymphohistiocytosis (HLH).

Reference range First episode of sHLH (May 2012, other center) Second episodes of sHLH (May 2015)
White cell count (per mm3) 3.9–5.6 1.99 2.72
 Neutrophils (per mm3) 2.1–6.43 1.84
 Lymphocytes (per mm3) 1.37–6.81 0.78
 Monocytes (per mm3) 0.24–0.71 0.03
Hemoglobin (g/dl) 11.5–16.5 8.8 11.4
Platelet count (per mm3) 150–450 125 124
C-reactive Protein (mg/dl) 0–0.46 2.1 5.56
Erythrocyte sedimentation rate (mm/h) 1–12 18
Serum amyloid A (mg/L) 0–6.4 121
Triglycerides (mg/dl) 30–160 254
Aspartate aminotransferase (U/L) 0–35 450
Alanine aminotransferase (U/L) 0–35 590
Lactate dehydrogenase (U/L) 84–480 1,195 2,524
Ferritin (ng/ml) 20–200 1,164 1,773
Immunoglobulin A (mg/dl) 34–305 31 84
Immunoglobulin M (mg/dl) 500–1,560 448 1,041
Immunoglobulin G (mg/dl) 25–210 29 28
IgG anti-diphtheria (UI/ml) 0.2
IgG anti-tetanus (UI/ml) 0.45
PCR-CMV Negative Negative
PCR-EBV Negative Negative
EBV-IgM 0–0.9 <0.8 <0.8
PCR-Parvovirus B19 Positive Slightly positive
Parvovirus B19—IgM 0–17 35 negative
Parvovirus B19—IgG 0–11.5 20 62.1
Bone marrow aspiration Macrophages with hemophagocytosis
CD3+ (n/mmc) 1,400–2,000 651.3
CD3+ (%) 66–76 83.5
CD3+ CD4+ (n/mmc) 700–1100 429
CD3+ CD4+ (%) 33–41 55
CD3+ CD8+ (n/mmc) 600–900 187.2
CD3+ CD8+ (%) 27–35 24
CD3+ HLA-DR+ % 9.5–17 5.7
CD19+ (n/mmc) 300–500 106.08
CD19+ (%) 12–22 13.6
CD16+ CD56+ CD3- (n/mmc) 200–300 17.6
CD16+ CD56+ CD3- (%) 9–16 2.2
% CD3+ TCRα/β CD4- CD8- (DNTc) (%) <2.5% 1.9