Table 1.
Reference range | First episode of sHLH (May 2012, other center) | Second episodes of sHLH (May 2015) | |
---|---|---|---|
White cell count (per mm3) | 3.9–5.6 | 1.99 | 2.72 |
Neutrophils (per mm3) | 2.1–6.43 | 1.84 | |
Lymphocytes (per mm3) | 1.37–6.81 | 0.78 | |
Monocytes (per mm3) | 0.24–0.71 | 0.03 | |
Hemoglobin (g/dl) | 11.5–16.5 | 8.8 | 11.4 |
Platelet count (per mm3) | 150–450 | 125 | 124 |
C-reactive Protein (mg/dl) | 0–0.46 | 2.1 | 5.56 |
Erythrocyte sedimentation rate (mm/h) | 1–12 | 18 | |
Serum amyloid A (mg/L) | 0–6.4 | 121 | |
Triglycerides (mg/dl) | 30–160 | 254 | |
Aspartate aminotransferase (U/L) | 0–35 | 450 | |
Alanine aminotransferase (U/L) | 0–35 | 590 | |
Lactate dehydrogenase (U/L) | 84–480 | 1,195 | 2,524 |
Ferritin (ng/ml) | 20–200 | 1,164 | 1,773 |
Immunoglobulin A (mg/dl) | 34–305 | 31 | 84 |
Immunoglobulin M (mg/dl) | 500–1,560 | 448 | 1,041 |
Immunoglobulin G (mg/dl) | 25–210 | 29 | 28 |
IgG anti-diphtheria (UI/ml) | 0.2 | ||
IgG anti-tetanus (UI/ml) | 0.45 | ||
PCR-CMV | Negative | Negative | |
PCR-EBV | Negative | Negative | |
EBV-IgM | 0–0.9 | <0.8 | <0.8 |
PCR-Parvovirus B19 | Positive | Slightly positive | |
Parvovirus B19—IgM | 0–17 | 35 | negative |
Parvovirus B19—IgG | 0–11.5 | 20 | 62.1 |
Bone marrow aspiration | Macrophages with hemophagocytosis | ||
CD3+ (n/mmc) | 1,400–2,000 | 651.3 | |
CD3+ (%) | 66–76 | 83.5 | |
CD3+ CD4+ (n/mmc) | 700–1100 | 429 | |
CD3+ CD4+ (%) | 33–41 | 55 | |
CD3+ CD8+ (n/mmc) | 600–900 | 187.2 | |
CD3+ CD8+ (%) | 27–35 | 24 | |
CD3+ HLA-DR+ % | 9.5–17 | 5.7 | |
CD19+ (n/mmc) | 300–500 | 106.08 | |
CD19+ (%) | 12–22 | 13.6 | |
CD16+ CD56+ CD3- (n/mmc) | 200–300 | 17.6 | |
CD16+ CD56+ CD3- (%) | 9–16 | 2.2 | |
% CD3+ TCRα/β CD4- CD8- (DNTc) (%) | <2.5% | 1.9 |