Table 3.

Main advantages and disadvantages of non-viral vectors for cancer treatment.

	DNA	RNA
Advantages	Non-infective platforms	Non-infective platforms
	Easy to design and edit	Easy to design and edit
	Economic synthesis	Economic synthesis
	Induce specific immune responses	Induce specific immune responses
	High stability	Non-genetic integration
Disadvantages	Poor immunogenic	Poor immunogenic
	Low transfection efficiency	Low transfection efficiency
	Unknown side effects	Unwanted inflammatory responses
	May require a special administration device	Requires low temperatures for storage
	Potential integration into the human genome	Low stability