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Schematic representation of the RNA constructs. The CHIKV replicase is encoded on a non-replicating mRNA with optimized 5′ UTR and 3′ UTR [31]. The CHIKV and RRV envelope proteins are encoded on TR-RNAs under the control of the CHIKV SGP (TR-C and TR-R). Both TR-RNAs contain the CHIKV CSEs, the first 231 nt of nsP1, and the last 1818 nt of nsP4. CHIKV sequences are indicated in blue and RRV in red.
