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. 2022 Sep 12;14(9):2016. doi: 10.3390/v14092016

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Characterization of B.1.617.2 (Delta) and B.1.1.529 (Omicron) epitope-specific CD8 T cells in convalescent COVID-19 patients. (a, left) Representative data for the detection of epitope-specific CD8 T cells in HLA-A2+ convalescent COVID-19 patients who recovered from COVID-19 infection at 7 (top) and 50 days (bottom) with tetramers prepared using B.1.617.2 (Delta) and B.1.1.529 (Omicron) epitopes. (a, right) Overall statistics and comparison of CD8 T cells specific to B.1.617.2 (Delta) and B.1.1.529 (Omicron) epitopes in convalescent COVID-19 patients. Data are summarized as the mean ± SD. n = 6 for each group. (b) Fitted curves for ancestral (left) and mutant (right) B.1.617.2 (Delta) epitopes at 7 and 50 days after the third dose of vaccination and 7 and 50 days after recovery from COVID-19 infection. (c) Fitted curves for ancestral (left) and mutant (right) B.1.1.529 (Omicron) epitopes at 7 and 50 days after the third dose of vaccination and 7 and 50 days after recovery from COVID-19 infection.