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The multi−layered anti−prion system. Prions are attenuated by anti−prion systems at multiple levels, such as formation, transmission, propagation, segregation, and pathogenesis, and are affected (blocked) by at least one system. Most recently, the cooperation of some of these systems was reported to repress the generation or propagation of [PSI+] prions. * Btn2p and Cur1p have different effects on different yeast prions, [PSI+], and [URE3], but are listed here as anti-prion systems.
