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. 2022 Sep 11;27(18):5898. doi: 10.3390/molecules27185898

Figure 4.

Figure 4

Solution competition between heparin and heparin oligosaccharides/desulfated heparins. (A) SPR sensorgrams of MPXV A29–heparin interaction competing with different oligo-heparins. Concentration of MPXV A29 is 250 nM mixed with 1000 nM of different oligo-heparins. (B) Bar graphs (based on triplicate experiments with standard deviation) of normalized MPXV A29 binding preference to surface heparin, by competing with different oligo-heparins. (C) SPR sensorgrams of MPXV A29–heparin interaction competing with different desulfated heparins. Concentration of MPXV A29 is 250 nM mixed with 1000 nM of different desulfated heparins. (D) Bar graphs (based on triplicate experiments with standard deviation) of normalized MPXV A29 binding preference to surface heparin, by competing with different desulfated heparins.