| Juvederm Ultra 2,3,4 |
Allergan |
Hylacross technology |
Lasts 12 months; contain a high ratio of high MW HA vs. lower MW HA |
| Juvederm Volux, Voluma, Volift, Volbella, Volite |
Allergan |
Vycross technology |
Lasts up to 18 months; contain a higher proportion of low MW HA vs. higher MW HA |
| Saypha Filler, Volume, Volume Plus |
Croma |
Supreme Monophasic and Reticulated Technology (SMART) |
- |
| Restylane Vital, Vital light, Restylane, Restylane Lyft |
Galderma |
Non-animal stabilized hyaluronic acid technology (NASHA) |
Lasts 6 months on average, with retreatment every 6–9 months; addition of small amounts of BDDE introduces minute amounts of crosslinks between the individual chains, leading to entangled matrix |
| Restylane Fynesse, Refyne, Kysse, Volyme, Defyne |
Galderma |
Optimal balance technology (OBT) |
Thicker or thinner fillers are obtained by varying gel calibration, and firmer or softer fillers by varying crosslinking |
| Yvoire Classic, Volume Contour |
LGChem |
High Concentration Equalized crosslinking technology (HICE) |
Has a maximal rate of crosslinking, minimal alteration in HA structure, and optimization of dispersion of the crosslinking agent |
| Belotero Soft, Balance, Intense, Volume, Lips-Shape, Lips-Contour |
Merz |
Cohesive Polydensified Matrix (CPM) |
Lasts up to 12 months; monophasic polydensified gel that combines high levels of crosslinked HA with lighter levels of crosslinked HA in a cohesive matrix |
| Definisse Fillers |
RELIFE |
eXcellent Three-dimensional Reticulation (XTR™) technology |
A mixture of different lengths of HA chains are intermolecularly bound by a crosslinking agent to produce a stable three-dimensional HA matrix |
| Teosyal RHA 1, 2, 3, 4, Kiss |
Teoxane |
Resilient Hyaluronic Acid (RHA) |
Lasts 6–9 months; produces gels with long HA chains stabilized by natural and chemical crosslinks |
| Stylage Hydromax, S, M, L, Lip, XL, XXL |
Vivacy |
Interpenetrating Network like (IPN-Like) |
Use several individual crosslinked matrices, which undergo an interpenetrating network-like process to achieve a monophasic gel with an increased density of crosslinking |
