Figure 3.

NAb durability of second and third mRNA vaccine doses by manufacturer. NAb test timepoints represented as percent neutralization are pre-2nd/3rd (within one week), post-2nd/3rd (2–4 weeks after second or third dose), and monthly for 6–8 months after vaccination. (A) Longitudinal 2nd-dose data of BNT162b2 (Pfizer) in comparison to mRNA-1273 (Moderna). (B) Longitudinal 3rd-dose data. (C) Longitudinal 3rd-dose data of individuals that received the same vaccine type for all three vaccine doses, in comparison to individuals that received two Pfizer doses and a Moderna booster dose. Data are shown as grouped box and whisker plots with error bars representing 5th–95th percentile of each population. Outliers outside of the 5th–95th percentile are shown as circular symbols above or below error bars. Graphs A and B data were analyzed using nonparametric Mann–Whitney test to evaluate mean rank between groups with a two-tailed p-value (p < 0.05) and 95% confidence interval (CI). Graph C data were analyzed using a nonparametric Kruskal–Wallis test to evaluate mean rank between groups using multiple comparisons (two-tailed p < 0.05 and 95% CI). Titers corresponding to percent neutralization ranges are described (see Figure 2 legend). * p < 0.05, ** p <0.005, *** p < 0.0005.