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. 2022 Aug 25;12(9):1308. doi: 10.3390/life12091308

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gene expression for both P14 and P28 mGluR5^+/+ and mGluR5^+/- pups are depicted for: (A) NCAN (n = 3 P14 mGluR5^+/+, n = 3 P14 mGLuR5^+/-, n = 5 P28 mGluR5^+/+, n = 6 P28 mGluR5^+/-); (B) MMP9 (n = 4 P14 mGluR5^+/+, n = 4 P14 mGLuR5^+/-, n = 6 P28 mGluR5^+/+, n = 6 P28 mGluR5^+/-); (C) TNR (n = 4 P14 mGluR5^+/+, n = 3 P14 mGLuR5^+/-, n = 6 P28 mGluR5^+/+, n = 6 P28 mGluR5^+/-); (D) ACAN (n=4 P14 mGluR5^+/+, n = 3 P14 mGLuR5^+/-, n = 6 P28 mGluR5^+/+, n = 6 P28 mGluR5^+/-); and (E) HAPLN1 (n=4 P14 mGluR5^+/+, n = 4 P14 mGLuR5^+/-, n = 6 P28 mGluR5^+/+, n = 6 P28 mGluR5^+/-). All gene expression results are normalized to mGluR5^+/+ pups. Blue represents mGluR5^+/+, and red represents mGluR5^+/⁻. * p < 0.05, ** p < 0.01, **** p < 0.0001.