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. 2022 Aug 25;12(9):1308. doi: 10.3390/life12091308

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Total time (s) spent in open arms of the elevated plus maze (n = 11 mGluR5^+/-, n = 2 mGluR5^+/+, n = 2 SD Control). (B) Total number of entries into the open arm (n = 11 mGluR5^+/-, n = 2 mGluR5^+/+, n = 2 SD Control). (C) Overlaid heat maps of time spent in various zones for mGluR5^+/+, mGluR5^+/-, and mGluR5^-/- pups (n = 11 mGluR5^+/-, n = 2 mGluR5^+/+, n = 2 mGluR5^-/-). (D) Total distance moved in the elevated plus maze of male and female mGluR5+/- pups (n = 8 M, n = 8 F). (E) Average velocity (cm/s) of the pup center point in the elevated plus maze of male and female mGluR5+/- pups (n = 8 M, n = 6 F). (F) Total distance (cm) moved in the open field test (n = 3 mGluR5^+/+, n = 7 mGluR5^+/-). (G) Average center point velocity (cm/s) in the open field test (n = 3 mGluR5^+/+, n = 7 mGluR5^+/-).