Table 2.
Multivariate Cox regression analysis of factors that influenced OS and CSS outcomes.
| Factors | Median OS (Months) HR (95% CI) | p-Value | Median CSS (Months) HR (95% CI) |
p-Value |
|---|---|---|---|---|
| Age (years) | ||||
| <65 | Reference | |||
| ≥65 | 1.196 (0.903–1.584) | 0.213 | 1.167 (0.871–1.564) | 0.301 |
| Gender | ||||
| Female | Reference | |||
| Male | 0.900 (0.705–1.148) | 0.394 | 0.946 (0.732–1.221) | 0.946 |
| Tumor location | ||||
| Renal pelvis | Reference | |||
| Ureter | 0.782 (0.592–1.034) | 0.085 | 0.715 (0.530–0.965) | 0.028 |
| Ureter orifice | 1.044 (0.656–1.662) | 0.855 | 1.023 (0.630–1.662) | 0.926 |
| (T)NM | ||||
| 1–2 | Reference | |||
| 3–4 | 1.16 (0.869–1.553) | 0.312 | 0.946 (0.732–1.221) | 0.668 |
| T(N)M | ||||
| 0 | Reference | |||
| ≥1 | 0.962 (0.733–1.262) | 0.777 | 1.003 (0.753–1.337) | 0.983 |
| Number of organ metastasis | ||||
| Single organ site | Reference | |||
| Multiple organ sites | 1.425 (1.159–1.753) | <0.001 | 1.417 (1.141–1.760) | 0.002 |
| Radical nephroureterectomy | ||||
| No | Reference | |||
| Yes | 0.675 (0.514–0.886) | 0.005 | 0.671 (0.505–0.891) | 0.006 |
| Distant metastasis | ||||
| Lymph node | Reference | |||
| Liver | 1.732 (1.234–2.430) | 0.001 | 1.531 (1.062–2.207) | 0.022 |
| Bone | 1.188 (0.849–1.663) | 0.315 | 1.219 (0.863–1.721) | 0.261 |
| Lung | 1.179 (0.861–1.615) | 0.304 | 1.138 (0.817–1.585) | 0.444 |
| Chemotherapy | ||||
| No | Reference | |||
| Yes | 0.405 (0.313–0.523) | <0.001 | 0.435 (0.333–0.570) | <0.001 |