Table 2.
DSPC network analysis. Degree of node and betweenness of the interrelationships calculated on the metabolites with VIP > 1 related to the early and advanced ALS patients.
| Network Analysis Related to Early Patients | ||
|---|---|---|
| Label | Degree | Betweenness |
| L-Histidine | 16 | 59.91 |
| TG 54:5 | 15 | 58.3 |
| L-Glutamine | 15 | 32.01 |
| Acetic acid | 14 | 45.95 |
| CE 16:0 | 14 | 40.1 |
| Cer 42:1;O2 | 13 | 33.92 |
| PE O-38:5 | 13 | 31.09 |
| L-Valine | 13 | 27.77 |
| Malonic acid | 13 | 23.08 |
| L-Fucose | 12 | 51.26 |
| SM 41:1;O2 | 12 | 32.34 |
| 1-Methylhistidine | 12 | 24.22 |
| L-Arginine | 12 | 20.99 |
| L-Methionine | 12 | 18.84 |
| Betaine | 11 | 38.48 |
| TG 52:2 | 11 | 25.04 |
| TG 56:6 | 11 | 24.16 |
| Linoleamide | 11 | 20.78 |
| Oleamide | 11 | 20.36 |
| 3-(3,4,5-Trimethoxyphenyl)propanoic acid | 10 | 32.28 |
| Cer 42:0;O3 | 10 | 19.77 |
| TG 48:2 | 10 | 19.28 |
| L-isoleucyl-L-proline | 10 | 15.43 |
| TG 52:4 | 10 | 13.13 |
| L-Glutamic acid | 10 | 10.19 |
| SM(34:1) | 10 | 4.89 |
| Ornithine | 9 | 15.13 |
| Acetone | 9 | 14.81 |
| PC 35:2 | 9 | 11.77 |
| 3-Hydroxybutyric acid | 9 | 7.81 |
| Succinic acid | 9 | 6.81 |
| LPC(20:3) | 8 | 31.8 |
| Creatinine | 8 | 13.73 |
| Creatine | 8 | 10.52 |
| Isobutyric acid | 8 | 7.92 |
| PC 32:0 | 8 | 3.67 |
| PC O-40:5 | 7 | 8.09 |
| PC O-38:5 | 7 | 6.29 |
| TG 50:2 | 7 | 2.66 |
| L-Tryptophan | 6 | 20.66 |
| Citric acid | 5 | 9.23 |
| Indoxyl sulfate | 4 | 6.16 |
| LPC(18:2) | 3 | 3.01 |
| L-Isoleucine | 3 | 0.35 |
| 4-Hydroxyestrone sulfate | 2 | 0 |
| Network analysis related to advanced patients | ||
| Label | Degree | Betweenness |
| 3-Hydroxybutyric acid | 10 | 88.58 |
| L-Isoleucyl-L-proline | 10 | 75.85 |
| L-Fucose | 10 | 70.7 |
| Succinic acid | 9 | 89.14 |
| Betaine | 8 | 74.67 |
| TG 50:2 | 7 | 83.66 |
| 1-Methylhistidine | 6 | 65.9 |
| TG 48:2 | 6 | 64.41 |
| L-Methionine | 6 | 37.13 |
| L-Histidine | 6 | 32.1 |
| Isobutyric acid | 6 | 19.31 |
| LPC(18:2) | 5 | 100.12 |
| L-Valine | 5 | 75.3 |
| L-Isoleucine | 5 | 72.02 |
| PC 32:0 | 5 | 65.74 |
| L-Tryptophan | 5 | 62.42 |
| TG 52:2 | 5 | 58.58 |
| PC O-40:5 | 5 | 54.62 |
| Acetone | 5 | 45.33 |
| SM(34:1) | 5 | 33.5 |
| Acetic acid | 5 | 29.88 |
| 4-Hydroxyestrone sulfate | 5 | 29.83 |
| Cer 42:1 | 5 | 28.68463 |
| Creatinine | 5 | 27.83 |
| Malonic acid | 4 | 65.18 |
| TG 56:6 | 4 | 33.45 |
| Citric acid | 4 | 18.85 |
| 3-(3-45-Trimethoxyphenyl-propanoic acid) | 3 | 88.1 |
| CE 16:0 | 3 | 28.59 |
| TG 52:4 | 3 | 21.78 |
| L-Arginine | 3 | 19.99 |
| LPC(20:3) | 3 | 15.73 |
| PC 38:5 | 3 | 11.94 |
| Ornithine | 3 | 0.5 |
| Oleamide | 2 | 42 |
| Creatine | 2 | 9.23 |