Alteration in relative and absolute numbers of major CD8+ T cell subsets with varying patterns of CD45RA and CD62L expression in acute and convalescent COVID-19 patients. Scatter plots (A–D) and (E–H) show the percentages and absolute numbers of ‘naïve’ (CD45RA+CD62L+), central memory (CM, CD45RA−CD62L+), effector memory (EM, CD45RA−CD62L−), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA+CD62L−) CD8+ T cells, respectively. Black circles denote patients with acute COVID-19 (COV, n = 71); black squares—convalescent COVID-19 individuals (CON, n = 51); white circles—healthy control (HC, n = 46). Each dot represents individual subjects, and horizontal bars depict the group medians and quartile ranges (Med (Q25; Q75)). In Figure 4, the statistical analysis was performed with the Mann–Whitney U test.