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. 2022 Aug 28;14(9):1906. doi: 10.3390/v14091906

Figure 7.

Figure 7

Imbalance in peripheral blood Tc1, Tc2, Tc17, and Tc17.1 cells in major CD8+ T cell subsets with varying patterns of CD45RA and CD62L expression in acute and convalescent COVID-19 patients. Scatter plots (A–D), (E–H), (I–L), and (M–P) show the relative numbers of Tc1 (CCR6−CXCR3+), Tc2 (CCR6−CXCR3−), Tc17 (CCR6+CXCR3−), and double-positive Tc17.1 (CCR6+CXCR3+) cells within ‘naïve’ (CD45RA+CCR7+), central memory (CM, CD45RA−CCR7+), effector memory (EM, CD45RA−CCR7−), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA+CCR7−) CD8+ T cells, respectively. Black circles denote patients with acute COVID-19 (COV, n = 71); black squares—convalescent COVID-19 individuals (CON, n = 51); white circles—healthy control (HC, n = 46). Each dot represents individual subjects, and horizontal bars depict the group medians and quartile ranges (Med (Q25; Q75)). In Figure 7, the statistical analysis was performed with the Mann–Whitney U test.