Table 4.
The overview of all registered clinical trials of M. oleifera.
| Status | Official Title | Intervention/ Treatment |
Outcome Description | Study Design |
|---|---|---|---|---|
| Completed Duration: December 2012–August 2014 |
Safety and efficacy of Chandrakanthi Choornam in Oligospermia—A preclinical and clinical study | Drug: Chandrakanthi Choornam (CKC)—formulation consisting of 25 ingredients Conditions: Oligospermia |
Determination of sperm concentration, motility, and proportion of sperm morphology, as well as the effects on hormonal level. | Primary Purpose: Treatment Allocation: N/A Interventional Model: Single Group Assignment Masking: None (Open Label) |
| Completed Duration: January 2013–September 2013 |
Effect of M. oleifera (Moringa, Drumstick/Horseradish Tree) on the pharmacokinetics of Efavirenz and Nevirapine in-vivo. | Dietary Supplement: M. oleifera Drug: Efavirenz (600 mg) and Nevirapine (200 mg) *Oral Tablet Conditions: HIV |
Pharmacokinetic endpoints include area under the curve (AUC), time to maximum plasma concentration (tmax), peak plasma concentration (Cmax), trough concentration (Cmin), clearance (CL), volume of distribution (Vd/F) and half-life (T1/2). | Observational Model: Case-Crossover Time Perspective: Prospective Biospecimen Retention: SAMPLES_WITH_DNA Biospeciman Description: Whole Blood, Plasma, Urine |
| Completed Duration: January 2013–April 2014 |
Impact of dried M. oleifera leaves as value added supplement in enhancing hemoglobin status of reproductive aged females of low socio-economic group | Dietary Supplement: Dried M. oleifera leaves Conditions: Anemia, iron deficiency |
Improvement in hemoglobin status and body mass index. | Primary Purpose: Supportive Care Allocation: Non-Randomized Interventional Model: Single Group Assignment Masking: None (Open Label) |
| Completed Duration: August 2014–November 2014 |
The effects of M. oleifera supplements on hsCRP and HgbA1c levels of patients in Hospital Ng Maynila Medical Center diabetic clinic: A prospective cohort study | Dietary Supplement: M. oleifera Conditions: Diabetes |
Post treatment means of inflammatory markers HsCRP and hgba1c. | Primary Purpose: Supportive Care Allocation: N/A Interventional Model: Single Group Assignment Masking: None (Open Label) |
| Completed Duration: January 2014–April 2022 |
An observational clinical study to determine the effect of multi-modal Ayurvedic treatment in the patients of chronic kidney disease | Other: Ayurveda treatment Conditions: Diabetic nephropathy, hypertensive nephropathy |
The determination of the signs and symptoms as well as the improvement in metabolic profiles. | Primary Purpose: Treatment Allocation: N/A Interventional Model: Single Group Assignment Masking: None (Open Label) |
| Completed Duration: July 2015–May 2016 |
Effect of M. oleifera on bone density in post-menopausal Women | Dietary Supplement: M. oleifera Dietary Supplement: Cabbage placebo Conditions: Osteoporosis, osteopenia, postmenopausal, osteoporosis |
Bone density determined by dual-energy X-ray absorptiometry. | Primary Purpose: Basic Science Allocation: Randomized Interventional Model: Parallel Assignment Masking: Double |
| Completed Duration: March 2016–April 2016 |
Evaluation of the effect of M. oleifera tea on metformin steady state plasma level in type 2 diabetes mellitus patients—A pre and post non-randomised trial | Dietary Supplement: M. oleifera tea Conditions: Type 2 diabetes mellitus |
Changes in fasting blood glucose, 2 h post prandial blood glucose, metformin plasma concentration, estimated glomerular filtration rate. | Primary Purpose: Treatment Allocation: N/A Interventional Model: Single Group Assignment Masking: None (Open Label) |
| Completed Duration: November 2016–May 2017 |
Short term cardiovascular and renal effects of M. oleifera extracts and Stevia Rebaudiana Bertoni as add-on therapy in a population of type II diabetes individuals | Dietary Supplement: MOROLSTEVER1 (Capsules of M. oleifera and Stevia Rebaudiana Bertoni) Conditions: Type 2 diabetes mellitus |
Determination of diastolic function, early diastolic filling velocity, urinary excretion of albumin and changes in blood pressure. | Primary Purpose: Treatment Allocation: N/A Interventional Model: Single Group Assignment Masking: None (Open Label) |
| Completed Duration: December 2017–August 2020 |
Evaluation of the effect of Artemisia annua and M. oleifera on immunological response in HAART HIV patients | Dietary Supplement: Artemisia Annua, M. oleifera Conditions: HIV infections |
Determination of CD4 counts, viral load, complete blood count, immunoglobins, antiretroviral plasma drug level, patients’ perceptions on mental and physical quality of life, liver function biomarkers, side effects or adverse drug reactions, renal function biomarkers. | Primary Purpose: Treatment Allocation: Randomized Interventional Model: Parallel Assignment Masking: Double |
| Completed Duration: September 2018–March 2019 |
MORINGA; Delivering nutrition and economic value to the people of Malawi | Other: Control corn soya diet Other: Test corn, moringa diet Conditions: Malnourishment |
Determination of phytochemical metabolite concentration in systemic circulation. | Primary Purpose: Prevention Allocation: Randomized Interventional Model: Crossover Assignment Masking: None (Open Label) |
| Completed Duration: January 2019–January 2021 |
Effects of M. oleifera Leaves on glycemia, lipemia and inflammatory profile: Nutritional intervention study in prediabetic patients | Dietary Supplement: Moringa Dietary Supplement: Placebo Conditions: Pre-diabetes |
Determination of fasting blood glucose and glycated hemoglobin (HbA1C), conversion rate from prediabetes to normal, concentration of total serum cholesterol, lipoprotein–cholesterol, inflammatory markers and metabolic hormones, antioxidant capacity and microbiota composition. | Primary Purpose: Prevention Allocation: Randomized Interventional Model: Parallel Assignment Masking: Quadruple |
| Completed Duration: January 2020–March 2021 |
An evaluation of the effects of a non-caffeinated energy dietary supplement on cognitive and physical performance: A randomized double-blind placebo-controlled study | Dietary Supplement: Phytovive, placebo, caffeine Conditions: Health behavior |
Evaluation of cognition, mood and physical performance. | Primary Purpose: Basic Science Allocation: Randomized Interventional Model: Parallel Assignment Masking: Double |
| Unknown status Duration: February 2020–July 2020 |
Effect of aerobic training and M. oleifera on dyslipidemia and cardiac endurance | Other: Aerobic training and M. oleifera Conditions: Dyslipidemias |
Change in level of HDL, LDL and triglycerides, impact on cardiac endurance. | Primary Purpose: Health Services Research Allocation: Randomized Interventional Model: Parallel Assignment Masking: None (Open Label) |
| Unknown status Duration: February 2020–August 2020 |
Randomized clinical study investigating the effect of M. oleifera infusion on bioclinical parameters of health | Dietary Supplement: M. oleifera tea Conditions: Metabolic syndrome |
Change in blood glucose level, LDL cholesterol and triglyceride level as well as antioxidants of blood (e.g., superoxide dismutase, glutathione peroxidase, total blood antioxidant capacity). | Primary Purpose: Other Allocation: Randomized Interventional Model: Crossover Assignment Masking: Single |
| Completed Duration: March 2021–June 2022 |
Effect of M. oleifera capsule in increasing breast milk volume in early postpartum patients: A double blind randomized controlled trial | Drug: M. oleifera leaf Drug: Placebo Conditions: Postpartum women |
Determination of breast milk volume at postpartum day 3, as well as percentage of good satisfaction, quality of life scores, side effects and compliance. | Primary Purpose: Other Allocation: Randomized Interventional Model: Parallel Assignment Masking: Quadruple |
| Completed Duration: July 2021–November 2021 |
Investigating the impact of M. oleifera leaf supplementation on growth, nutrition, lactation, and inflammation in Kenyan breastfeeding mothers and children | Dietary Supplement: M. oleifera (high dose and low dose) Dietary Supplement: Placebo Conditions: Malnutrition, wasting, growth failure |
Changes in physical descriptions (body weight, height, mid-upper arm and head circumference) and metabolite levels (vitamin A, C-reactive protein, soluble transferrin–ferritin index, fecal neopterin, fecal myeloperoxidase, alpha-1-antitrypsin). The prevalence of diarrhea and changes in breast milk (output, vitamin A, retinol, vitamin E, catalase, lactoferrin) were also determined. | Primary Purpose: Prevention Allocation: Randomized Interventional Model: Single Group Assignment Masking: Single |
| Active, not recruiting Duration: December 2021–October 2022 |
Effects of M. oleifera mouthwash in patients undergoing fixed orthodontic appliance treatment: A parallel arm, triple blinded, randomized controlled trial | Other: M. oleifera mouthwash Other: Placebo mouthwash Conditions: Gingivitis, periodontitis, plaque formation, enamel demineralization/white spot lesion, discoloration and bacterial load in dental plaque (orthodontic appliance complication) |
Periodontal probing depth, plaque index, white spot lesions, modified gingival index, discoloration of teeth, bacterial load in plaque. | Primary Purpose: Prevention Allocation: Randomized Interventional Model: Parallel Assignment Masking: Quadruple |
| Completed Duration: February 2021– December 2021 |
Antifungal potential of M. oleifera-loaded nanoparticles against otomycosis; Preparation, characterization, and Clinical Evaluation | Drug: M. oleifera leaf 10 mg/100 mL Drug: Ear drop Conditions: Otomycosis |
The number of participants recovered with clear endoscopic examination and identification of different microorganisms that infected ear were determined. | Primary Purpose: Treatment Allocation: Randomized Interventional Model: Parallel Assignment Masking: None (Open Label) |
| Active, not recruiting Duration: April 2021–February 2022 |
Child health, agriculture, and integrated nutrition (CHAIN): A randomized trial to close the nutrient gap in rural Zimbabwe | Dietary Supplement: Small-quantity lipid-based nutrient supplement, provitamin A biofortified maize, NUA-45 biofortified sugar beans, M. oleifera, whole egg powder and white maize meal Conditions: Stunting |
Determinations of protein, iron, zinc, folate and energy intake, height and weight for age score, hemoglobin level, microbiome maturity, environmental enteric dysfunction, innate immune cell phenotype and function, plasma essential amino acids and choline, as well as urinary metabolic secretion. | Primary Purpose: Prevention Allocation: Randomized Interventional Model: Parallel Assignment Masking: Single |
| Recruiting Duration: August 2021–March 2022 |
A randomized, double-blind, cross-over, placebo-controlled study to explore the effect of M. oleifera (E-HS-01) on flow mediated dilatation and hemodynamics | Other: M. oleifera (E-HS-01) Other: Placebo Conditions: Endothelial function |
Determination of flow-mediated dilatation and blood flow velocity. | Primary Purpose: Other Allocation: Randomized Interventional Model: Crossover Assignment Masking: Quadruple |
| Recruiting Duration: April 2022–July 2022 |
Evaluation of the anti-plaque and anti-gingivitis effects of Moringa plant extract and fluoride toothpastes among a group of Egyptian children: A randomized clinical trial | Drug: M. oleifera leaf Conditions: Oral disease |
Determination of gingival index and plaque index. | Primary Purpose: Treatment Allocation: Randomized Interventional Model: Parallel Assignment Masking: Double |
| Recruiting Duration: May 2022–May 2023 |
Investigating the effect of M. oleifera leaf powder on breastmilk quantity and quality: A double blinded randomized placebo-controlled trial | Dietary Supplement: Moringa leaf powder Other: Placebo Conditions: Breastfeeding |
Differences in milk output, species prevalence of infant microbiome and maternal milk microbiome, maternal milk fat and protein, infant fecal and maternal milk microbiome composition, maternal milk vitamin A. | Primary Purpose: Treatment Allocation: Randomized Interventional Model: Parallel Assignment Masking: Quadruple |
| Not yet recruiting Duration: July 2022- December 2023 |
Antibacterial, antiplaque and anticariogenic effect of M. oleifera mouthwash compared to chlorhexidine mouthwash: A randomized clinical trial | Drug: M. oleifera, chlorhexidine mouthwash, base formula Conditions: Plaque, dental antimicrobial, mouthwash cytotoxicity |
Determinations of gingival index (GI) and white spot lesions. | Primary Purpose: Prevention Allocation: Randomized Interventional Model: Parallel Assignment Masking: Double |
| Not yet recruiting Duration: August 2022–April 2023 |
Effect of M. oleifera leaf extract versus sodium hypochlorite as root canal irrigant on postoperative pain and bacterial reduction in mandibular premolars with necrotic pulps: A randomized clinical trial | Dietary Supplement: M. oleifera leaf Drug: Sodium hypochlorite Conditions: Necrotic pulp |
Determinations of postoperative pain and intracanal bacterial load change. | Primary Purpose: Treatment Allocation: Randomized Interventional Model: Parallel Assignment Masking: Double |