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. Author manuscript; available in PMC: 2022 Sep 23.
Published in final edited form as: Neurobiol Dis. 2022 Feb 8;166:105655. doi: 10.1016/j.nbd.2022.105655

Figure 6. PCA identifies top altered functions in AD astrocytes.

Figure 6.

A. PCA analysis of astrocyte-enriched genes in ROSMAP. Dot plots and violin plots along PC1 (mean ± SEM) show differential expression of astrocyte genes in type 2 vs type 1 subjects.

B. Top varying genes in PC1 (up-regulated and down-regulated), color-coded for function according to the circos plot, inform about functions altered in AD astrocytes. The vertical axis represents the relative contribution (importance/weight) of each gene for the scoring of individual samples in panel A along PC1.

C. Scoring of MtSINAI and MAYO databases using genes overlapping with ROSMAP PCA in A. discriminates Control and AD cohorts along PC1, as shown by the dot and violin plots (means ± SEM).