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. 2022 Sep 15;23(18):10766. doi: 10.3390/ijms231810766

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The relationships of m6A regulators and key AD genes. (A) PPI network was constructed by 14 m6A regulators as well as 19 key AD genes, with the disconnected proteins being hidden. Wider lines indicate stronger evidence of protein interactions. (B,C) The t-test was conducted to analyze the difference in the expression of NOTCH2 and NME1 between normal controls and AD patients. (D,E) The Pearson’s test was performed to analyze the correlation between NOTCH2 and NME1 and m6A regulators. The results with significant differences was marked as *** p < 0.001.