Table 1.

List of the 25 m6A regulators included in the current study.

Categories	m6A Regulators	Mechanisms	References
m6A writers	METTL3	Catalyzes m6A modification	[7]
	METTL5	Affects the selection of methylation sites	[10]
	METTL14	Assists METTL3 in recognizing the substrates substraction	[8]
	WTAP	Promotes METTL3-METTL14 heterodimer to the nuclear speckle	[11]
	RBM15/15B	Binds the m6A complex and recruits it to special RNA site	[12,13]
	ZC3H13	Bridges WTAP to the mRNA-binding factor Nito	[14]
	KIAA1429	Guides methyltransferase components to specific RNA regions	[15]
	ZCCHC4	Adds m6A to18S and 28S ribosomal RNAs	[17]
	CBLL1	Binds the m6A evolutionary conserved protein complex	[16]
	PCIF1	Catalyzes m6A methylation on 2-O-methylated adenine	[18]
m6A erasers	FTO	Removes m6A modification	[19]
	ALKBH5	Removes m6A modification	[20]
m6A readers	YTHDC1	Promotes RNA splicing and translocation	[21]
	YTHDC2	Enhances the translation of target RNA	[22]
	YTHDF1	Promotes mRNA translation	[23]
	YTHDF2	Reduces mRNA stability	[25]
	YTHDF3	Mediates the translation or degradation	[24]
	EIF3H	Interacts with METTL3 and enhances translation	[26]
	FMR1	Affects the nuclear export of m6A-modified RNA targets	[27]
	IGF2BP1/2/3	Enhances mRNA stability	[28]
	HNRNPC	Mediates mRNA splicing	[29]
	HNRNPA2B1	Promotes primary microRNA processing	[30]