Table 2.

The role and regulation of genes connected with arachidonic acid metabolism in cells after AGR2 knockout and in response to TGF-β treatment as clustered by DAVID analysis tool.

Gene	Regulation	Function
PLA2G4A	DOWN	Hydrolysis of membrane phospholipids, which leads to release of arachidonic acid that is further metabolized into eicosanoids through one of three pathways (COX, LOX, CYP450) [58].
PTGS2	DOWN	Also known as COX-2, a rate-limiting enzyme involved in the conversion of arachidonic acid into prostaglandins [58].
PTGES	DOWN	Enzyme catalyzing conversion of COX derived PDH2 into PGE2 [59].
AKR1C3	DOWN	Downstream of COX catalyzes reduction of PGH2 and PGD2 into PGF2α [60].
GPX2	DOWN	Reduces fatty acid-derived hydroperoxides and inhibits NF-κB activity [61].