Table 4.
Characterization of tadalafil-loaded liquid self-nanoemulsifying drug delivery systems (TDL-L-SNEDDS) formulations.
| Code | VO | PT (%) | SET (Sec) | Robustness to Dilution |
ADS (nm) | PDI | ZP (mV) | Thermodynamic Stability Tests | ||
|---|---|---|---|---|---|---|---|---|---|---|
| H/C | CT | F/T Test | ||||||||
| F1 | B | 90.1 ± 1.7 | 39 ± 0.33 | No | 198 ± 8.7 | 4.5 ± 1.80 | −4.7 ± 0.3 | X | - | - |
| F2 | B | 92.3 ± 2.4 | 37 ± 0.43 | Yes | 222 ± 7.6 | 3.20 ± 0.97 | −5.8 ± 0.27 | √ | X | - |
| F3 | A | 95.7 ± 1.1 | 29 ± 0.37 | Yes | 159 ± 4.7 | 0.24 ± 0.03 | −11.9 ± 0.82 | √ | √ | √ |
| F4 | A | 96.3 ± 1.6 | 25 ± 0.77 | Yes | 132 ± 6.8 | 0.45 ± 0.09 | −17.8 ± 0.18 | √ | √ | √ |
| F5 | A | 97.9 ± 1.3 | 23 ± 0.34 | Yes | 45 ± 6.9 | 1.24 ± 0.16 | −18.1 ± 0.25 | √ | √ | √ |
| F6 | A | 98.8 ± 1.8 | 20 ± 0.29 | Yes | 32 ± 4.6 | 1.35 ± 0.37 | −19.7 ± 0.41 | √ | √ | √ |
Mean ± SD; n = 3; SD, standard deviation; L-SNEDD, liquid self-nanoemulsifying drug delivery systems; VO, visual observation; PT, percentage transmittance; SET, self-emulsification time; AGS, average droplet size (ADS); PDI, polydispersity index; ZP, zeta potential; CT, centrifugation test; H/C cycle, heating cooling test; F/T test, freeze/thaw test.