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Pharmacokinetic parameters of TDL in rats after oral administration (1 mg/kg, n = 6).
| PK Parameter | SNECT | DCT | MT |
|---|---|---|---|
| Cmax, ng mL−1 | 125.2 ± 6.6 | 54.2 ± 3.2 | 97.8 ± 4.3 |
| tmax (h) | 2.0 ± 0.3 | 2.1 ± 0.2 | 1.90 ± 0.3 |
| AUC 0–24 h (ng × h × mL−1) | 1403.0 ± 70.2 | 263.4 ± 14.7 | 930.0 ± 47.4 |
| t ½ (h) | 6.63 ± 0.8 | 4.90 ± 0.4 | 6.70 ± 0.3 |
PK, pharmacokinetic parameter; SNECT, self-nanoemulsified chewable tablets; DCT, direct compressible tablets; MT, marketed tablets.
