Skip to main content
. 2022 Sep 15;12(9):1438. doi: 10.3390/life12091438
ADMET Absorption, Distribution, Metabolism, Excretion, Toxicity
AlogP Computationally Derived LogP
BEI Binding Efficiency Index
BLI Biolayer Interferometry
bRo5 Beyond Rule of Five
CE Capilary Electrophoresis
ClogP Computationally Derived LogP
CryoEM Cryo-Electron Microscopy
DSF Differential Scanning Fluorimetry
EE Enthalpic Efficiency
FBDD Fragment-Based Drug Discovery
GCI Grating-Coupled Interferometry
GE Group Efficiency
HA Heavy Atoms
HBA Hydrogen Bond Acceptors
HBD Hydrogen Bond Donors
HTS High Throughput Screening
IDP Intrinsically Disordered Protein
ITC Isothermal Titration Calorimetry
LE Ligand Efficiency
LipE Lipophilic Efficiency
LLE Ligand Lipophilic Efficiency
LogP Logarithm of Octanol/Water Partition Coefficient
MST Microscale Thermophoresis
NME New Molecular Rntities
NMR Nuclear Magnetic Resonance
NNH Number of non-hydrogen atoms
NP Natural Products
PAINS Pan-Assay Interference Compounds
PSA Polar Surface Area
QSAR Quantitative Structure-Activity Relationships
Ro3 Rule of Three
Ro5 Rule of Five
ROTB Rotatable Bonds
SBDD Structure-Based Drug Design
SIHE Size Independent Enthalpic Efficiency
SPR Surface Plasmon Resonance
TPSA Topological Polar Surface Area
TSA Thermal Shift Assay
WAC Weak Affinity Chromatography