Table 1.
Summary of the data regarding (i) the involvement of TRPV1 sensory fibers in the pathophysiology of lower urinary tract dysfunctions (LUTD), (ii) the relevance of acute intravesical capsaicin instillation (AICI) in rodents to mimic the condition, (iii) clinical trials assessing the effect of vanilloids for the treatment of the condition and (iv) main outcomes of the clinical trials. RTX—resiniferatoxin, SCI—spinal cord injury.
| LUTD | Involvement of TRPV1 Receptors in LUTD | AICI in Rodents |
Clinical Trials Assessing the Effect of Vanilloids |
Clinical Efficiency of Vanilloids |
|---|---|---|---|---|
| OAB/DO | Yes | Yes | Yes | RTX decreased incontinence episodes and improved quality of life |
| NDO | Yes | Yes | Yes | Capsaicin decreased incontinence episodes in incomplete SCI |
| BOO | Yes | Yes | No | - |
| IC/PBS | Yes | Yes | Yes | RTX did not improve symptoms |