Table 1.
List of analysed genes and their assignment to cellular pathways.
| Pathway | Symbol | Gene Name |
|---|---|---|
| Angiogenesis | ANGPT1 | Angiopoietin 1 |
| ANGPT2 | Angiopoietin 2 | |
| CCL2 | Chemokine (C-C motif) ligand 2 | |
| FGF2 | Fibroblast growth factor 2 | |
| FLT1 | Fms-related tyrosine kinase 1 | |
| KDR | Kinase insert domain receptor | |
| PGF | Placental growth factor | |
| SERPINF1 | Serpin peptidase inhibitor, clade F member 1 | |
| TEK | TEK tyrosine kinase, endothelial | |
| VEGFC | Vascular endothelial growth factor C | |
| Apoptosis | APAF1 | Apoptotic peptidase activating factor 1 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | |
| BIRC3 | Baculoviral IAP repeat containing 3 | |
| CASP2 | Caspase 2 | |
| CASP7 | Caspase 7 | |
| CASP9 | Caspase 9 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | |
| FASLG | Fas ligand (TNF superfamily, member 6) | |
| NOL3 | Nucleolar protein 3 (apoptosis repressor) | |
| XIAP | X-linked inhibitor of apoptosis | |
| Cell cycle | AURKA | Aurora kinase A |
| CCND2 | Cyclin D2 | |
| CCND3 | Cyclin D3 | |
| CDC20 | Cell division cycle 20 homolog (S. cerevisiae) | |
| E2F4 | E2F transcription factor 4, p107/p130-binding | |
| MCM2 | Minichromosome maintenance complex component 2 | |
| MKI67 | Antigen identified by monoclonal antibody Ki-67 | |
| SKP2 | S-phase kinase-associated protein 2 (p45) | |
| STMN1 | Stathmin 1 | |
| WEE1 | WEE1 homolog (S. pombe) | |
| Cellular senescence | BMI1 | BMI1 polycomb ring finger oncogene |
| ETS2 | V-Ets erythroblastosis virus E26 oncogene homolog 2 | |
| IGFBP3 | Insulin-like growth factor binding protein 3 | |
| IGFBP5 | Insulin-like growth factor binding protein 5 | |
| IGFBP7 | Insulin-like growth factor binding protein 7 | |
| MAP2K1 | Mitogen-activated protein kinase kinase 1 | |
| MAP2K3 | Mitogen-activated protein kinase kinase 3 | |
| MAPK14 | Mitogen-activated protein kinase 14 | |
| SERPINB2 | Serpin peptidase inhibitor, clade B, member 2 | |
| SOD1 | Superoxide dismutase 1, soluble | |
| TBX2 | T-box 2 | |
| DNA damage and repair | DDB2 | Damage-specific DNA binding protein 2, 48kDa |
| DDIT3 | DNA-damage-inducible transcript 3 | |
| ERCC3 | Excision repair cross-complementing rodent repair deficiency, complementation group 3 | |
| ERCC5 | Excision repair cross-complementing rodent repair deficiency, complementation group 5 | |
| GADD45G | Growth arrest and DNA-damage-inducible, γ | |
| LIG4 | DNA Ligase 4, ATP-dependent | |
| POLB | DNA Polymerase beta | |
| PPP1R15A | Protein phosphatase 1, regulatory subunit 15A | |
| Epithelial-to-mesenchymal transition (EMT) | CDH2 | Cadherin 2, type 1, N-cadherin (neuronal) |
| DSP | Desmoplakin | |
| FOXC2 | Forkhead box C2 | |
| GSC | Goosecoid homeobox | |
| KRT14 | Keratin 14 | |
| OCLN | Occludin | |
| SNAI1 | Snail homolog 1 (Drosophila) | |
| SNAI2 | Snail homolog 2 (Drosophila) | |
| SNAI3 | Snail homolog 3 (Drosophila) | |
| SOX10 | SRY (sex determining region Y)-box 10 | |
| Hypoxiasignalling | ADM | Adrenomedullin |
| ARNT | Aryl hydrocarbon receptor nuclear translocator | |
| CA9 | Carbonic anhydrase 9 | |
| EPO | Erythropoietin | |
| HMOX1 | Heme oxygenase 1 | |
| LDHA | Lactate dehydrogenase A | |
| SLC2A1 | Solute carrier family 2, member 1 | |
| Metabolism | ACLY | ATP citrate lyase |
| ACSL4 | Acyl-CoA synthetase long-chain family member 4 | |
| ATP5A1 | Mitochondrial ATP synthase alpha subunit 1 | |
| COX5A | Cytochrome c oxidase subunit 5A | |
| CPT2 | Carnitine palmitoyltransferase 2 | |
| G6PD | Glucose-6-phosphate dehydrogenase | |
| GPD2 | Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | |
| LPL | Lipoprotein lipase | |
| PFKL | Phosphofructokinase, liver | |
| UQCRFS1 | Ubiquinol-cytochrome c reductase Rieske iron-sulfur polypeptide 1 | |
| Telomeres and telomerase | DKC1 | Dyskerin |
| PINX1 | PIN2/TERF1 interacting, telomerase inhibitor 1 | |
| TEP1 | Telomerase-associated protein 1 | |
| TERF1 | Telomeric repeat binding factor (NIMA-interacting) 1 | |
| TERF2IP | Telomeric repeat binding factor 2, interacting protein | |
| TINF2 | TERF1-interacting nuclear factor 2 | |
| TNKS | Tankyrase | |
| TNKS2 | Tankyrase 2 |