Table 2.
The MIC values (μg/mL) of different antifungals against seven Aspergillus fumigatus isolates as determined by the YeastOneTM and CLSI methods.
| Strain No. | AFST Method | ISA | POS | VRC | ITC | FLC | AMB |
|---|---|---|---|---|---|---|---|
| CGMHD 1497 |
YeastOne | ND | 0.03 | 0.5 | 0.06 | >256 | 4 |
| CLSI | 0.25 | 0.125 | 0.25 | 0.25 | >64 | 0.5 | |
| CGMHD 1524 |
YeastOne | ND | 0.03 | 0.5 | 0.06 | >256 | 4 |
| CLSI | 0.5 | 0.125 | 0.25 | 0.5 | >64 | 0.5 | |
| CGMHD 2417 |
YeastOne | ND | 0.03 | 0.5 | 0.06 | >256 | 4 |
| CLSI | 0.25 | 0.125 | 0.25 | 0.125 | >64 | 1 | |
| CGMHD 0641 |
YeastOne | ND | 0.03 | 1 | 0.12 | >256 | 1 |
| CLSI | 0.5 | 0.125 | 0.5 | 0.25 | >64 | 0.25 | |
| CGMHD 0744 |
YeastOne | ND | 0.06 | 1 | 0.12 | >256 | 2 |
| CLSI | 1 | 0.25 | 1 | 0.5 | >64 | 0.5 | |
| CGMHD 1652 |
YeastOne | ND | 0.5 | 8 | >16 | >256 | 2 |
| CLSI | 4 | 0.5 | 4 | >16 | >64 | 0.25 | |
| CGMHD 2261 |
YeastOne | ND | 0.5 | 1 | >16 | >256 | 2 |
| CLSI | >4 | 0.5 | 2 | >16 | >64 | 1 |
AFST—antifungal susceptibility testing; ND—not performed because isavuconazole is not included in the YeastOneTM panel; CLSI—Clinical and Laboratory Standards Institute, M38-3rd Ed. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi.