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. 2022 Sep 16;14(9):2061. doi: 10.3390/v14092061

Figure 3.

Figure 3

High ACE2 expression in target cells strongly reduces neutralization by monoclonal antibodies that bind spike epitopes outside the receptor-binding motif. Neutralization curves for three monoclonal antibodies that target different epitopes: Ly-CoV555 binds the RBD’s receptor-binding motif and competes with ACE2 binding, S309 binds a RBD epitope outside the receptor-binding motif, and 4A8 binds the NTD. The dashed gray line indicates zero infectivity. Neutralization assays were performed using D614G spike-pseudotyped lentiviral particles.