Table 2.
Cytochrome P450 enzyme system responsible for antipsychotic metabolism and the effects of race.
| Antipsychotics | Major Enzyme | Minor Enzyme | Minor Enzyme | Race effect of Cp: % E. Asian > Western |
|---|---|---|---|---|
| Haloperidol | CYP3A4 | CYP2D6 | 50 | |
| Clozapine | CYP1A2 | CYP3A4 | CYP2D6, CYP2C19 | 30–50 |
| Risperidone | CYP2D6 | CYP3A4 | -- | |
| Paliperidone | -- | CYP2D6 | -- | |
| Olanzapine | (Glucuronidation) | CYP1A2 | CYP2D6, CYP3A4 | -- |
| Quetiapine | CYP3A4 | CYP2D6 | 50–100 | |
| Ziprasidone | Aldehyde oxidase | CYP3A4 | 30-40 | |
| Aripiprazole | CYP2D6 | CYP3A4 | 50–100 | |
| Lurasidone | CYP3A4 | 30–40 | ||
| Brexpiprazole | CYP3A4 | CYP2D6 | NA |
CYP, Cytochrome P450; Cp, Plasma Concentration; NA, not available.