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Increased levels of C3a and C5b-9 in COVID-19 patients. C3a and C5b-9 levels measured on admission were higher in critically ill compared to patients with severe COVID-19 (a,b), in intubated versus non-intubated (c,d), and in non-survivors compared to survivors (e,f). Data are expressed as means ± SD. Statistical analysis was performed using the Mann–Whitney U test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
