. 2022 Sep 14;27(18):5990. doi: 10.3390/molecules27185990

Table 4.

The binding affinity of ligands and tyrosinase enzyme.

Compound Name	Binding Energy (kcal/mol)	Interacting Ligands at Binding Site of Enzyme
Compound Name	Binding Energy (kcal/mol)	Bonding Type	Binding Amino Acid
Kojic acid	−5.4	Hydrogen bonding Pi-Pi stacked Pi-Sigma	His60 His208 Val218
γ-tocopherol	−6.6	Hydrogen bonding Alkyl	Arg209, Gly213 Lys150, Val217
Campesterol	−6.5	Alkyl	Ala155
Phytol	−4.7	Alkyl	Lys150, Val217
Myristic acid	−4.5	Hydrogen bonding Alkyl	Arg280, Glu289, Arg165, Val168, Ley169, Ile237, Val240, Ile243, Ile288