Table 4.
Univariate analysis of baseline characteristics and management plan for overall survival in patients with T4 colorectal cancer.
| Variable | HR [95% CI] | p-Value |
|---|---|---|
|
Age more than 70 years
(vs. less than 70 years) |
1.030 [1–1.061] | 0.048 |
|
Male sex
(vs. Female) |
0.664 [0.324–1.361] | 0.264 |
|
BMI ≥ 30 kg/m2
(vs. < 30) |
0.756 [0.230–2.483] | 0.645 |
|
ASA ≥ 2
(vs. < 2) |
0.632 [0.241–1.658] | 0.351 |
|
Elevated CEA
(vs. low CEA) |
1.16 [0.558–2.411] | 0.690 |
|
Colon
(vs. rectum) |
0.921 [0.379–2.239] | 0.856 |
|
Synchronous liver metastases
(vs. no synchronous metastases) |
0.839 [0.255–2.757] | 0.008 |
|
Neoadjuvant treatment
(vs. no neoadjuvant treatment) |
0.964 [0.338–2.752] | 0.945 |
|
Emergent surgery
(vs. elective) |
1.422 [0638–3.168] | 0.389 |
|
Laparoscopic approach
(vs. open) |
0.382 [0.147–0.995] | 0.049 |
|
Multiple organ resection
(vs. no resection) |
1.074 [0.524–2.2] | 0.845 |
|
Synchronous liver resection
(vs. no synchronous liver resection) |
0.839 [0.255–2.757] | 0.772 |
|
N+ status
(vs. N0 status) |
1.517 [0.740–3.108] | 0.255 |
|
R1 margins
(vs. R0 margins) |
3.754 [1.273–11.07] | 0.017 |
|
Postoperative complications
(vs. no postoperative complications) |
1.393 [0.692–2.802] | 0.353 |
|
Grade III–IV complications
(vs. no major complications) |
0.964 [0.294–3.166] | 0.952 |
| CCI Score | 0.990 [0.9631.018] | 0.476 |
|
Adjuvant chemotherapy
(vs. no adjuvant chemotherapy) |
0.936 [0.431–2.031] | 0.867 |
ASA: American Score of Anesthesiologists; BMI: body mass index; CCI: Comprehensive Complication Index; CEA, carcinoembryonic antigen; CI: confidence interval; HR: hazard ratio; OS: overall survival.