TABLE 1.
Signature nucleotide substitutions unique to individual mutS clades of pathogenic E. coli strains a
| Clade no. | Nucleotide at position:
|
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 17 | 47 | 95 | 167 | 197 | 218 | 234 | 236 | 264 | 272 | 284 | 296 | 311 | 323 | 341 | 350 | 353 | |
| 1 | C/G | C | C | C | A | C | T | A | T | T | T | T | [A] | G | G | T | G |
| 2 | [T] | C | C | C | A | [T] | T | A | T | T | T | [C] | G | G | G | T | G |
| 3 | C | C | C | C | A | C | T | A | T | T | T | T | G | G | G | T | G |
| 4 | C | [A] | [G] | [T] | A | C | T | A | T | [C] | T | T | G | [A] | [A] | [C] | [A] |
| 5 | C | C | C | C | [G] | C | T | A | T | T | T | T | G | G | G | T | G |
| 6 | C/G | C | C | C/G | A | C | [C]b | [G] | [C]b | T | [C] | T | G | G | G | T | G |
a
Signature nucleotides unique to every member of each clade are bracketed. Nucleotide substitution positions were derived using the Clustal X multiple sequence alignment program (52) and visualized in MacClade v. 3.04 (35). Clade numbers correspond to clades reported in Fig. 3. All other substitutions shown are located in the third position of the codon and are also synonymous.
b
Synonymous first-position substitution.