Table 1.
Comparison of sensitivities (a) and specificities (b) of the Fungiplex Candida PCR and the Wako β-Glucan Test.
| a Candidemia Group |
All Samples n (%) |
PCR pos. n (%) |
BDG pos. n (%) |
Significance: p Value |
|---|---|---|---|---|
| Total cases | 103 (-) | 34 (33) | 60 (58) | 0.0002 |
| Underlying conditions | ||||
| Hemato-oncologic malignancy | 39 (37) | 16 (41) | 18 (46) | 0.7893 |
| HSCT | 20 (19) | 7 (35) | 9 (45) | 0.7518 |
| Solid organ transplantation | 14 (14) | 4 (29) | 10 (71) | 0.0771 |
| ICU | 47 (46) | 13 (28) | 28 (60) | 0.0023 |
| Sampling date of serum | ||||
| 0–2 days before BC | 63 (61) | 29 (46) | 39 (62) | 0.0890 |
| 3–5 days before BC | 28 (27) | 5 (18) | 16 (57) | 0.0026 |
| 6–7 days before BC | 12 (12) | 0 (0) | 5 (42) | 0.0736 |
| Species isolated | ||||
| Candida albicans | 49 (48) | 18 (37) | 28 (57) | 0.0244 |
| Candida glabrata | 18 (17) | 3 (17) | 8 (44) | 0.1306 |
| Candida parapsilosis | 12 (12) | 3 (25) | 8 (67) | 0.1842 |
| Candida krusei | 8 (8) | 3 (38) | 6 (75) | 0.2482 |
| Others | 41 (16) | 7 (44) | 10 (63) | 0.5050 |
|
b
Control Group |
All Samples
n (%) |
PCR neg.
n (%) |
BDG neg.
n (%) |
Significance:
p Value |
| Total controls | 46 (-) | 43 (93) | 41 (89) | 0.7237 |
| BC result | ||||
| Staphylococcus aureus | 13 (28) | 12 (92) | 13 (100) | 1.0000 |
| Escherichia coli | 15 (33) | 13 (87) | 12 (80) | 1.0000 |
| Sterile | 18 (39) | 18 (100) | 16 (89) | 0.4795 |
Two-tailed p values were calculated using McNemar’s test with continuity correction. Results at a significance level < 0.05 are in bold. pos., positive; neg., negative; BDG, β-1,3-D-glucan; HSCT, hematopoietic stem cell transplantation; ICU, intensive care unit; BC, blood culture.