Table 2.
Table summarizing the references dealing with silica NPs@RB, including the type of NPs, as well as their size, excitation wavelength, type of detection of 1O2, type of coupling between the NPs and the RB, and the type of biological experiments performed.
| PDT Silica NPs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| References | Type of NPs | Size of NPs (nm) |
Irradiation Conditions | Type of 1O2 Detection | Type of Coupling between NPs and RB | Biological Tests/In Vitro | Biological Test/In Vivo | ||
| Cells Used | Results | Mice Used | Results | ||||||
| [63] | Ln:ZrO2@SiO2@RB | 20–25 thick | 633 nm, 4 mW He-Ne laser, 10 min | DPBF | Covalent | HeLa | Cytotoxicity (+) | nd | nd |
| [50] | Mesoporous silica NPs@RB | 160–180 | green light, 5 min | nd | Covalent | SK-MEL-28 | Cytotoxicity (+) | nd | nd |
| [59] | Silica coated (Gd3Al5O12:Ce3+)-RB | 74.13 ± 9.04 | 470 nm, 20 mW/cm2, 15–30–45 min | DPBF | Loaded | MDA-MB-231 | Cytotoxicity (+) | nd | nd |
| [58] | MSN@DOX@RB | 200 | 532 nm, 0.5 W/cm2, 5 min | nd | Covalent | MCF-7 | Cytotoxicity (+) | nd | nd |
| [57] | MSN@C-dots/RB | 104 | 540 nm, 300 mW/cm2, 5 min | DPBF | Encapsulation | H1299 | Cytotoxicity (+) | nd | nd |
| [54] | UCN/SiO2-RB DOX)@PPADT | 38.2 ± 3.6 | 980 nm, 1.0 W/cm2, 20 min | ABDA | Covalent | HeLa | Cytotoxicity (+) | nd | nd |
| [55] | SiNP-AAP-RB | 5–15 | 410 nm, 1.6 J/cm2, 15 min | Direct | Covalent | A549 | Cytotoxicity (+) | nd | nd |
| [52] | Silica capped rMSN-ts | Lenght 33 ± 27 and width 103 ± 15 | 5 mV green laser, 30 s | Direct | Covalent | MCF7 L269 |
Cytotoxicity (+) | nd | nd |
| [53] | FITC-PGSN-RB | 100 | 480 nm, 100 W xenon lamp, 10 min | ABDA | Adsorption | HeLa | Cytoxicity (+) | nd | nd |
| [51] | RB-MSNs NPs | 150–180 | nd | Direct | Encapsulation | nd | nd | nd | nd |
| [62] | RB-DOX@HMSNs | 170 | 532 nm, 10 mW/cm2, 5 min | DPBF | Encapsulation | 4T1 | Cytotoxicity (+) | nd | nd |
| [61] | RB@ZIF-8@SiO2@RB NPs (drug loaded MOFs@SiO2 NPs) | 93.8 | 532 nm, 200 mW/cm2, 2 min or 100 mW/cm2, 7 min | DPBF | Encapsulation | 4T1 | Cytotoxicity (+) | BALB/c mice bearing AT1 tumors | PDT (+) |
| [56] | RB–MMSNs | 190 | 535 nm, 25 mW/cm2, 3 min | Uric acid | Encapsultation | B16 HeLa L929 |
Cytotoxicity (+) | C57BL/6J mice | PDT (+) |
| [64] | RB-PEG5000-MSNs | 50 | 518 nm, 10 J/cm2, 5 min | Direct | Covalent | HeLa | Cytotoxicity (+) | nd | nd |
| [49] | RB-SiNP | electrostatic = 35 ± 5 covalent = 50 ± 5 |
480 nm, 1 h (fluence not cited) |
SOSG | Covalent/Electrotatic | MCF-7 4451 |
Cytoxicity (+) | nd | nd |
nd: not determined; cytotoxicity (+): induced tumor cell death in vitro; PDT (+): induced tumor death in vivo.