Table 3.

DAPK1 kinase % inhibition activity for the final target compounds 4a–r at 10 µM.

Cpd	% Inhibition against DAPK1 a	Cpd	% Inhibition against DAPK1 a
4a	44.19	4j	79.06
4b	58.95	4k	80.61
4c	58.83	4l	61.83
4d	50.91	4m	61.73
4e	59.98	4n	61.54
4f	64.06	4o	37.99
4g	50.18	4p	61.48
4h	81.00	4q	72.10
4i	63.69	4r	59.98

^a % enzyme inhibition (relative to DMSO controls) for all synthesized analogs in a single-dose duplicate mode assay at a concentration of 10 µM with DAPK1 kinase.