Fig. 2.

(A) Cells exposed to direct contact with WSNT (see scheme in Fig.1A, top) showed a moderate drop in metabolic activity (here, HASMC cells; HUVEC in Fig S12C). Direct contact with ZnO induced strong cytotoxicity at nominal dose ≥ 5.9 µg/cm². Mean and standard error of mean plotted. All statistical tests were performed against control samples; stars indicate the magnitude of adjusted p-value (* P≤0.05, ** P≤0.01, ***P≤0.001, **** P≤0.0001). (B) Cellular metabolic activity levels, inferred from the WST-1 assay (see scheme in Fig. 1B, top), show no statistical difference in viability between HASMC cells treated with PLA disks and PLA nanocomposite (0.1% of WSNT or ZnO) disks (see Fig. S12D for HUVEC). Experiments were performed twice with four replicates per condition. Experiment-specific mean and standard deviation are plotted. All statistical tests were performed against the PLA condition; stars indicate the magnitude of adjusted p-value (* P≤0.05, ** P≤0.01, *** P≤0.001, **** P≤0.0001).