Table 3.

Recombinant products with the expiry of the gene patents.

1: Albumin [1990-11-16]; 2: Insulin [2004-03-24]; 3: Interferon beta-1b [2004-03-28]; 4: Parathyroid hormone [2004-04-21]; 5: Interferon alfa-2b [2004-12-28]; 6: Plasma protein fraction [2005-01-19]; 7: Natalizumab [2005-01-30]; 8: Asparaginase [2005-03-08]; 9: Filgrastim [2005-08-23]; 10: Rho d immune globulin [2006-11-25]; 11: Gonadotropin, chorionic [2007-01-30]; 12: Sebelipase alfa [2007-04-17]; 13: Anakinra [2008-12-24]; 14: Alemtuzumab [2010-05-11]; 15: Abciximab [2010-09-14]; 16: Interferon alfa-n3 [2011-03-01]; 17: Antihemophilic factor/von willebrand factor complex [2011-07-19]; 18: Aldesleukin [2012-02-03]; 19: Etanercept [2012-03-07]; 20: Epoetin alfa [2012-08-15]; 21: Thrombin [2012-09-09]; 22: Ibritumomab tiuxetan [2012-11-13]; 23: Pegfilgrastim [2013-12-03]; 24: Bevacizumab [2014-01-25]; 25: Reslizumab [2014-06-17]; 26: Cetuximab [2014-08-10]; 27: Trastuzumab [2014-08-10]; 28: Trastuzumab hyaluronidase-oysk [2014-08-10]; 29: Pegaspargase [2014-10-20]; 30: Von willebrand factor [2014-11-14 ]; 31: Denileukin diftitox [2015-02-01]; 32: Rituximab [2015-02-01]; 33: Hyaluronidase [2015-02-01]; 34: Sargramostim [2015-02-01]; 35: Imiglucerase [2015-03-24]; 36: Menotropins (fsh, lh) [2015-09-29]; 37: Palifermin [2015-09-29]; 38: Urofollitropin [2015-09-29]; 39: Peginterferon alfa-2b [2015-11-02]; 40: Basiliximab [2016-05-16]; 41: Daclizumab [2016-05-16]; 42: Alteplase [2016-05-22]; 43: Equine thymocyte immune globulin [2016-09-05]; 44: Denosumab [2016-12-23]; 45: Insulin lispro [2017-01-10]; 46: Infliximab [2017-04-04]; 47: Panitumumab [2017-05-05]; 48: Adalimumab [2017-09-26]; 49: Blinatumomab [2018-04-21]; 50: Insulin aspart [2018-05-19]; 51: Rilonacept [2018-09-25]; 52: Romiplostim [2018-10-23]; 53: plasma proteins [2018-12-10]; 54: Interferon beta-1a [2020-01-14]; 55: Interferon gamma-1b [2020-01-14]; 56: Palivizumab [2020-05-03]; 57: Capromab pendetide [2020-08-21]; 58: Ranibizumab [2020-08-24]; 59: Gemtuzumab ozogamicin [2020-11-28]; 60: Ocriplasmin [2020-12-21]; 61: Abatacept [2021-02-15]; 62: Golimumab [2021-03-07]; 63: Rasburicase [2021-05-01]; 64: Dornase alfa [2021-09-04]; 65: Tenecteplase [2021-10-30]; 66: Insulin detemir [2021-11-19]; 67: Laronidase [2021-11-30]; 68: Follitropin alfa/beta [2022-01-22]; 69: Pertuzumab [2022-05-17]; 70: Peginterferon alfa-2a [2022-08-01]; 71: Corticorelin ovine triflutate [2022-08-05]; 72: Omalizumab [2022-08-14]; 73: Darbepoetin alfa [2022-08-29]; 74: Pegvisomant [2023-01-09]; 75: Imciromab pentetate [2023-03-05]; 76: Thyrotropin alfa [2023-06-24]; 77: Agalsidase beta [2023-10-01]; 78: Selumetinib [2023-12-12]; 79: Albiglutide [2025-01-04]; 80: Antihemophilic factor [2025-01-04]; 81: Insulin aspart [2025-01-04]; 82: Lixisenatide [2025-01-04]; 83: Methoxy polyethylene glycol-epoetin beta [2025-01-04]; 84: Aflibercept [2025-03-15]; 85: Ramucirumab [2025-03-15]; 86: Belimumab [2025-05-20]; 87: Insulin glulisine [2025-05-23]; 88: Certolizumab pegol [2025-11-08]; 89: Ipilimumab [2025-11-08]; 90: Fremanezumab-vfrm [2025-11-14]; 91: Calfactant [2026-01-10]; 92: Tocilizumab [2026-04-13]; 93: Eculizumab [2026-04-27]; 94: Inotuzumab ozogamicin [2026-06-23]; 95: Mepolizumab [2026-06-23]; 96: Ocrelizumab [2026-06-23]; 97: Ofatumumab [2026-06-23]; 98: Raxibacumab [2026-06-23]; 99: Coagulation factor ix [2026-07-13]; 100: Desirudin [2026-08-02]; 101: Poractant alfa [2026-11-02]; 102: Benralizumab [2027-01-11]; 103: Galsulfase [2027-06-13]; 104: Evolocumab [2027-08-23]; 105: Ustekinumab [2027-11-30]; 106: Capmatinib [2027-12-12]; 107: Ado-trastuzumab emtansine [2028-10-22]; 108: Belatacept [2028-12-05]; 109: Canakinumab [2030-03-29]; 110: Abobotulinumtoxina [2030-03-30]; 111: Asparaginase erwinia chrysanthemi [2030-03-30]; 112: Incobotulinumtoxina [2030-03-30]; 113: Dulaglutide [2030-05-05]; 114: Metreleptin [2030-05-05]; 115: Brentuximab vedotin [2030-05-26]; 116: Insulin degludec [2030-06-24]; 117: Necitumumab [2030-09-08]; 118: Brodalumab [2030-10-08]; 119: Secukinumab [2030-10-08]; 120: Nivolumab [2031-02-04]; 121: Pembrolizumab [2031-02-04]; 122: Insulin detemir [2031-04-01]; 123: Vedolizumab [2031-05-02]; 124: Elotuzumab [2031-08-05]; 125: Olaratumab [2031-08-05]; 126: Siltuximab [2031-08-05]; 127: Sarilumab [2031-10-11]; 128: Alirocumab [2031-10-25]; 129: Alirocumab [2031-10-25]; 130: Insulin degludec [2031-10-25]; 131: Liraglutide [2031-10-25]; 132: Insulin glargine [2031-10-25]; 133: Insulin lispro [2031-10-25]; 134: Ixekizumab [2031-10-25]; 135: Obinutuzumab [2031-10-25]; 136: Peginterferon beta-1a [2031-10-25]; 137: Daratumumab [2031-10-28]; 138: Somatropin [2031-12-05]; 139: Eptinezumab-jjmr [2031-12-12]; 140: Atezolizumab [2032-08-13]; 141: Avelumab [2032-08-14]; 142: Durvalumab [2032-08-14]; 143: Ziv-aflibercept [2032-10-31]; 144: Choriogonadotropin alfa [2033-02-06]; 145: Alglucosidase alfa [2033-03-11]; 146: Insulin susp isophane [2033-03-11]; 147: Sacrosidase [2033-03-11]; 148: Dupilumab [2033-03-14]; 149: Coagulation factor viia [2033-04-24]; 150: Bezlotoxumab [2033-09-09]; 151: Pemigatinib [2033-12-12]; 152: Sacituzumab govitecan-hziy [2033-12-12]; 153: Tucatinib [2033-12-12]; 154: Ravulizumab-cwvz [2034-03-07]; 155: Idarucizumab [2034-07-31]; 156: Dinutuximab [2034-10-06]; 157: Guselkumab [2035-02-24]; 158: Obiltoxaximab [2035-02-24]; 159: Isatuximab-irfc [2035-10-05]; 160: Taliglucerase alfa [2036-02-11]; 161: Velaglucerase alfa [2036-02-11]; 162: Polatuzumab vedotin-piiq [2039-10-22].