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. 2022 Sep 17;20(9):580. doi: 10.3390/md20090580

Figure 4.

Figure 4

Effect of HMWF on expression of tight junction (TJ) markers. Caco-2 cell monolayers were treated for 24 h with 500 μg/mL HMWF and 10 μM MG-H1 for 24 h. Mice were treated with 25 or 75 mg/kg b.w. HMWF orally and 400 μg/kg b.w. MG-H1 intravenously once a day for 4 weeks. (A) mRNA expression of TJ markers in Caco-2 monolayers and (B) mouse colon tissues. (C) Protein expression of TJ markers in Caco-2 monolayers and (D) mouse colon tissues. The results are shown as mean ± standard deviation. * p < 0.05 ** p < 0.01, *** p < 0.001 versus the control group, # p < 0.05, ### p < 0.001 versus the MG-H1-treated group.